Vanilla. Applying vanilla extract to a burn is another home remedy that can provide some relief. It has worked in many cultures for many years to help alleviate pain. The vanilla in the liquid helps soothe and soften the burned skin and the alcohol in the extract helps cool the burn and relieve pain as it evaporates. Gently dab a small amount of vanilla extract on the affected area with a cotton ball or swab and let it sit. An added benefit is its sweet, calming scent that helps with aromatherapy.